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Concomitant use of clarithromycin immediate release tablets and zidovudine in HIV-infected patients may cause a decrease in the equilibrium concentrations in the blood serum of zidovudine. This can be avoided in many respects by observing the interval between doses of clarithromycin and zidovudine. About this interaction in the application of suspension of clarithromycin and zidovudine or dideoksinazinu in children have been reported.
It is also possible right directional drug interaction between clarithromycin and atazanovirom, itraconazole, saquinavir.
pharmacological properties
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Protibakterialny, a bacteriostatic drug. It inhibits protein synthesis by binding to the ribosomal unit. Clarithromycin is highly active against a broad spectrum of aerobic and anaerobic gram-positive and gram-negative microorganisms: Pasteurella multocid, Borelliaburgdorferi, Mycobacterium (Mycobacterium avium including, Mycobacterium leprae, intracellulare, kansasii, fortuitum), Clostridium perfringens, Streptococcus agalactiae, Str. Pyogenes, Str. viridans, Str. pneumoniae, Haemophilus influenzae (parainfluenzae), Neisseria gonorrhoeae, Listeria monocytogenes, Legionella pneumophila, of Mycoplasma pneumoniae, Helicobacter (Campilobacter) pylori, of Campylobacter jejuni, Chlamydia pneumoniae (trachomatis), Moraxella (Branhamella) catarrhalis, Bordella pertussis, Propionibacterium acnes, Staphylococcus aureus, Ureaplasma urealyticum, Toxoplasma gondii.
Pharmacokinetics.