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Order biaxin Caution should be exercised when using clarithromycin to patients who receive therapy drugs - of CYP3A substrates, especially if the CYP3A-substrate has a narrow therapeutic range (eg, carbamazepine) and extensively metabolized by this enzyme. You may need to change the dose and, if possible, close monitoring of serum concentrations of the drug is metabolized by CYP3A in patients simultaneously receiving clarithromycin. It is known (or assumed) that such drugs or drug groups metabolized by the same CYP3A isoenzyme: alprazolam, astemizole, carbamazepine, cilostazol, cisapride, cyclosporin, disopyramide, ergot alkaloids, lovastatin, methylprednisolone, midazolam, omeprazole, oral anticoagulants (e.g. warfarin), pimozide, quinidine, rifabutin, sildenafil, simvastatin, tacrolimus, terfenadine, triazolam and vinblastine. Such a mechanism of interaction was observed with the use of phenytoin, theophylline and valproate metabolized other isoenzyme of cytochrome P450. Order biaxin Like other macrolides, clarithromycin induced increase in the concentration of HMG-CoA reductase inhibitors such as lovastatin and simvastatin. Rarely reported about the development of rhabdomyolysis in patients in the combined use of these drugs. omeprazole Use of clarithromycin in combination with omeprazole in healthy adult volunteers resulted in an increase of the equilibrium concentrations of omeprazole. In the application only the average value of omeprazole gastric pH was measured in 5.2, while the use of omeprazole with clarithromycin over 24 hours - 5.7. Order biaxin The combined use of clarithromycin and oral anticoagulants may potentiate the effect of the latter, which requires close monitoring of prothrombin time in patients. Sildenafil, tadalafil, and vardenafil
Категория: Order biaxin online | Добавил: Dnister (22.11.2016)
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