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Clarithromycin 500mg tablets price
Clarithromycin 500mg tablets price Clarithromycin is rapidly and well absorbed from the gastrointestinal tract after oral administration of the drug in tablet form. Microbiologically active metabolite 14-hydroxyclarithromycin formed by first-pass metabolism. Clarithromycin can be applied regardless of the meal, as food has no effect on the bioavailability of clarithromycin tablets. Food slightly delays the onset of absorption of clarithromycin and formation of the 14-gidroksimetabolita. Clarithromycin 500mg tablets price The equilibrium concentration of clarithromycin and its major metabolite in plasma (with regular ingestion of 250 mg) is approximately 1 ug / ml and 0.6 ug / ml, and half-life - 4.3 hours and 6.5 hours, respectively; at a dose of 500 mg - 2.7-2.9 g / ml and 0,83-0,88 mg / ml of half-life - 5-4,8 6,9-8,7 hours and hours respectively. In the application of 250 mg 2 times a day for 15-20% of the unchanged form excreted in the urine. At a dose of 500 mg 2 times daily urine output preparation vigorously (approximately 36%). 14 hydroxyclarithromycin is the main metabolite excreted in the urine in an amount of 10-15% of the dose. Most of the remainder of the dose is excreted in the faeces, mostly in the bile. 5-10% of the parent compound in feces. When applying clarithromycin 500 mg three times daily of clarithromycin plasma concentrations are increased as compared with a dose of 500 mg 2 times a day. Clarithromycin 500mg tablets price Clarithromycin concentration in tissues at several times higher than the concentration of drug in the blood. Elevated levels were detected in tonsillar and pulmonary tissues. Clarithromycin at therapeutic doses by 80% bound to plasma proteins. Clarithromycin penetrates the gastric mucosa. The content of clarithromycin and stomach mucosa tissue over the application of clarithromycin with omeprazole, clarithromycin than monotherapy.
Категория: Order biaxin online | Добавил: Dnister (22.11.2016)
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