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Clarithromycin is biotransformation in the liver with the participation of the enzyme system of cytochrome P450; wherein formed metabolites 8. Approximately 25% of the drug is metabolized in the 14-hydroxyclarithromycin defining antihemophilic activity of drugs, which decrease can be observed with significant hepatic dysfunction.
The metabolic products and the minimum of the unchanged drug is eliminated in the bile. The content of the active drug in the feces often negligible, but can be up to 500 mg / kg, corresponding to a concentration of telithromycin and other macrolides. Clarithromycin is the only macrolides creating clinically relevant concentrations in the urine: the kidneys displayed 20-40% unchanged drug and 10 to 15% as a 14-hydroxyclarithromycin.
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Indications for use.
• Lower respiratory tract infections (community-acquired pneumonia, exacerbation of chronic bronchitis / chronic obstructive pulmonary disease).
• Cystic fibrosis (combination therapy).
• H. pyfori-associated pathology (peptic ulcer disease, chronic gastritis, non-ulcer dyspepsia).
• Urogenital infections: urethritis, chlamydia, mycoplasmosis, gynecological infections.
• MAC-AIDS infection (treatment and prevention).
It is used in case of intolerance or ineffectiveness of beta-lactams or fluoroquinolones:
• upper respiratory tract infections (acute and chronic sinusitis, otitis media, acute streptococcal tonzilofaringit);
• periodontal infection;
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• uncomplicated skin and soft tissue infections caused by S. aureus and S. pyogenes.
The test readings:
• coronary heart disease, acute coronary syndrome;
• bronchial asthma.
Dosing and Administration
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