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On the part of the organ of vision: visual impairment and toxic optic neuropathy.
Co of the ear and vestibular apparatus: narusheniesluha, tinnitus and vertigo.
On the part of the hepatobiliary system: narusheniefunktsy liver, liver failure, hepatitis izheltuha.
Skin and subcutaneous tissue: sindromStivensa-Johnson and toxic epidermalnyynekroliz (ochenredko) reaktsiisvetochuvstvitelnosti.
On the part of the kidney and urinary tract: renal dysfunction, and toxic nephropathy in various forms, including interstitial nephritis, nephrotic syndrome and renal failure.
General disorders: malaise, fatigue.
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Ibuprofen is contraindicated in patients with hypersensitivity to the active substances or auxiliary product.
Ibuprofen should not be used by patients who had hypersensitivity reactions observed previously (eg, asthma, urticaria, angioneurotic edema or rhinitis) after administration of ibuprofen, aspirin or other NSAIDs.
Ibuprofen is also contraindicated in patients with gastrointestinal bleeding or perforation in the history related to previous treatment with ibuprofen. Ibuprofen should not be used by patients with recurrent peptic ulcer or gastrointestinal bleeding (two or more episodes of proven ulceration or bleeding).
Ibuprofen should not be administered to patients with conditions accompanied by an increased tendency to bleed.
Ibuprofen is contraindicated in patients with severe heart failure, hepatic and renal insufficiency.
Ibuprofen is contraindicated during the last trimester of pregnancy.
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Toxicity: The toxicity signs and symptoms are usually not observed when receiving doses below 100 mg / kg in children and adults. Nevertheless, in some cases it may be necessary maintenance therapy. In children, the signs and symptoms of toxicity are observed when ibuprofen 400 mg / kg and above.
Symptoms: Most patients who take a considerable amount of ibuprofen, the symptoms occurred within 4-6 hours.
The most common symptoms of overdose are nausea, vomiting, abdominal pain, lethargy, drowsiness. Symptoms of the central nervous system: headache, tinnitus, dizziness, convulsions, loss of consciousness. Rare: nystagmus, metabolic acidosis, hypothermia, renal effects, gastrointestinal bleeding, coma, apnea, diarrhea, depression of the central nervous system and respiratory system. There have also been marked by disorientation, agitation, loss of consciousness and cardiovascular toxicity, including hypotension, bradycardia and tachycardia. In cases of substantial overdose may be kidney failure and liver damage. A large overdose usually well tolerated, if not taken other drugs.