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Co gastro-intestinal: The most commonly observed adverse reactions are gastrointestinal. Peptic ulcer, perforation or gastrointestinal bleeding, sometimes fatal, can occur especially in the elderly. Nausea, vomiting, diarrhea, flatulence, constipation, dyspepsia, abdominal pain, melena, hematemesis, ulcerative stomatitis, exacerbation of colitis and Crohn's disease have been reported after administration of ibuprofen. Less developed gastritis. Rarely - perforation of the wall of the gastrointestinal tract. Very rarely - pancreatitis.
Immune system: hypersensitivity reactions have been reported after administration of the NSAID. In particular:
· Non-specific allergic reaction and anaphylaxis;
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· A violation of airway reactivity (asthma, bronchospasm or shortness of breath);
· Diverse manifestations in the skin (rashes of various types, pruritus, urticaria, purpura, angioedema and, more rarely, exfoliative and bullous dermatoses (including Stevens-Johnson syndrome, toxic epidermal necrolysis and erythema multiforme)).
Cardio-vascular system: edema, hypertension and symptoms of heart failure have been reported in the treatment of NSAID. Epidemiological data indicate that the use of ibuprofen, particularly at high doses (2400 mg / day), when prolonged treatment may cause a slight increase in arterial thrombosis which causes myocardial infarction or stroke.
From the blood system and lymphatic system: leukopenia, thrombocytopenia, neutropenia, agranulocytosis, aplastic anemia, and hemolytic anemia.
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Psychiatric disorders: insomnia, anxiety, depression, confusion, hallucinations.
Nervous system disorders: Optic neuritis, headache, paresthesia, dizziness, drowsiness.
Infections and infestations: Rhinitis and aseptic meningitis (especially in patients with existing autoimmune disorders such as systemic lupus erythematosus and mixed connective tissue disease), with symptoms of stiff neck, headache, nausea, vomiting, fever or disorientation.
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