Some groups
Elderly
Healthy elderly subjects (65 years or more) had lower values of clearance of tadalafil when taken internally, which led to an increase of 25% exposure (AUC) compared with healthy subjects aged 19-45 years. This effect of age is not clinically significant and does not require dose adjustment.
Kidney failure
Tadalafil on line
In subjects with renal nedosttatnistyu, including patients on dialysis, tadalafil exposure AUC was higher than in healthy men.
Hepatic insufficiency
Exposure tadalafil (AUC) in subjects with mild to moderate hepatic impairment is comparable to exposure in healthy subjects. There are no data on patients with severe hepatic impairment.
Patients with diabetes
Exposure tadalafil (AUC) in patients with diabetes was approximately 19% lower than the AUC value for healthy subjects. This difference in exposure does not require dose adjustment.
Indications. Treatment of erectile dysfunction.
Dosage and administration. For oral administration.
The recommended maximum dose is 20 mg before the alleged sexual activity, regardless of the meal. The drug can be taken 16 minutes before sexual activity. Efficacy of tadalafil may persist for up to 36 hours after taking the dose.
The maximum recommended frequency of admission - once a day.
Cialis should not be used by persons under the age of 18 years.
Tadalafil on line
Source: Cialis, instruction, use of the drug Cialis coated tablets, 20 mg number 1, number 2, number 4, number 8