Cialis improves erection and ability to successfully perform the sexual act. The drug acts within 36 hours. The effect occurs within 16 minutes after taking the dose in the presence of sexual arousal.
Cialis, introduced healthy subjects did not cause significant difference compared to placebo in terms of systolic and diastolic blood pressure in the supine position (mean maximum decrease 1,60,8 mm Hg. Art., Respectively), systolic and diastolic blood ' yanoho standing pressure (mean maximum decrease 0,24,6 mm Hg. Art., respectively) and a significant change in heart rate.
Tadalafil does not degrade the recognition of colors (blue, green), due to the low affinity of tadalafil on PDE 6 compared to PDE 5. In addition, there is no effect of tadalafil on visual acuity, elektroretynohramu, intra ocular pressure and pupil size.
Van placebo-control study showed that taking tadalafil for 6 months showed no clinically significant effect on sperm haraktkrystyky. Men tadalafil did not affect testosterone levels, lyutenizuyuchoho or follicle stimulating hormone levels
Pharmacokinetics.
Order cheap cialis.Tadalafil well absorbed after oral administration. The average maximum plasma concentration (Cmax) achieved an average of 2 hours after ingestion.
The rate and extent of absorption of tadalafil are not dependent on food intake; therefore, Cialis can be taken with or without food. Time dosing (morning versus evening) had no clinically meaningful effect on the rate and extent of absorption.
Distribution. The average volume of distribution is around 63 liters. At therapeutic concentrations, 94% of tadalafil in plasma is bound to proteins.
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Less than 0.0005% of the administered dose was found in semen of healthy subjects.
Metabolism. Tadalafil is metabolized mainly 3A isoform 4 cytochrome P450 (CYP). The major circulating metabolite is metylkateholhlyukuronid. This metabolite has a PDE 5 activity against at least 13,000 times less than tadalafil. Thus, it is expected that the metabolite is not to show clinical activity at concentrations observed.
Breeding. The average period of semi output is 17.5 hours in healthy subjects. Tadalafil is excreted predominantly as inactive metabolites, mainly with feces (approximately 61% of the dose) and to a lesser extent - in the urine (approximately 36% of the dose).
Some groups
Source: Cialis, instruction, use of the drug Cialis coated tablets, 20 mg number 1, number 2, number 4, number 8