| INSTRUCTION
medical use of the drug
C & L A and C.
(C I A L I S)
General characteristics:
International and chemical name: tadalafil; pirazynol [1 ', 2': 1,6] pyrydo
[3,4-b] indole-1,4-dione, 6- (1,3-benzodioksol-5-yl) -2,3,6,7,12,12a-heksahidro-
2-methyl, (6R, 12aR);
basic physical and chemical properties: tablets yellow and almond-shaped, marked "C 20" on one side;
Ingredients: 1 tablet contains 20 mg tadalafil;
Excipients: lactose monohydrate, croscarmellose sodium, hydroxypropyl cellulose, microcrystalline cellulose, sodium lauryl sulfate, magnesium stearate, hypromellose, triacetin, titanium dioxide (E 171), iron oxide yellow (E 172), talc.
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Product. Coated tablets.
Pharmacological group. Funds for the treatment of erectile dysfunction.
ATC Code G04B E.
Pharmacological properties. Pharmacodynamics. Tadalafil is a selective reversible inhibitor of cyclic huanozynmono phosphate (cGMP) - Special-nographic phosphodiesterase type 5 (PDE5). When sexual stimulation causes local release of nitric oxide, inhibition of PDE5 tadalafil produces increased levels of cGMP in the cavernous body. This results in smooth muscle relaxation and inflow of blood to the tissues of the penis, creating an erection. Tadalafil has no effect without sexual stimulation.
Studies in vitro have shown that tadalafil is a selective inhibitor of PDE 5 is an enzyme PDE5, which was found in smooth muscles of the cavernous body, vascular and visceral smooth muscle, skeletal muscle, platelets, kidney, lung, and cerebellum. Effect of tadalafil for PDE5 is stronger than other phosphodiesterase. Effects of tadalafil for PDE5 in 10 000 times greater than its effect on the enzyme PDE 1, PDE 4 and PDE 2 PDE 7, which is present in the heart, brain, blood vessels, liver, leukocytes, skeletal muscle and other organs. Tadalafil is 10 000 times stronger on PDE5 versus PDE 3, which is an enzyme present in the heart and blood vessels. This selective on PDE5 versus PDE 3 is important because PDE 3 is an enzyme that plays a role in cardiac contraction. Additionally, tadalafil about 700 times stronger on PDE5 versus PDE 6, which is an enzyme present in the retina and responsible for the photo transduction. Tadalafil also 9,000 times more powerful on PDE5 versus PDE 8 - PDE PDE 9 and 10, and 14 times more powerful on PDE5 versus PDE 11. Distribution in tissues and physiological effects of PDE PDE 11 8 chrez not highlighted.
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Source: Cialis, instruction, use of the drug Cialis coated tablets, 20 mg number 1, number 2, number 4, number 8
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