Interaction with other medicinal products. It is not expected that tadalafil will cause clinically significant inhibition or induction of the clearance of drugs metabolized by CYP450 isoforms. Studies have confirmed that tadalafil does not inhibit and does not induce CYP450 isoforms, including CYP3A4, CYP1A2, CYP2D6, CYP2C19, CYP2E CYP2S 1 and 9.
Tadalafil is metabolized predominantly CYP3A4. Selective inhibitor of CYP3A4 - ketoconazole (400 mg daily) increased the area under the curve "concentration-time" (AUC) of a single dose of tadalafil in 312% and Cmax by 22% and ketakonazol (200 mg daily) increased the AUC of a single dose of tadalafil by 107% and Cmax 15% with respect to AUC and Cmax values for tadalafil one.
Cialis for women
Ritonavir (200 mg twice daily), inhibitorCYP3A4, 9 2C, 2C 19, 2D6 and increased AUC of a single dose tadalvfilu to 124% without changing the C max. Although specific interactions have not been investigated, we can expect that other protease inhibitors, such as saquinavir, and other inhibitors of CYP3A4, such as erythromycin, itraconazole, will increase the concentration of tadalafil in plasma.
CYP3A4 inducer - rifampicin (60 mg daily) - reduces the value of a single dose of tadalafil AUC by 88% and Cmax by 46% compared to the AUC and Cmax values for tadalafil alone. It is expected that concomitant administration of other inducers of CYP3A4 also lowers the concentration of tadalafil in plasma.
Cialis for women
Tadalafil had no clinically significant effect on exposure (AUC) S-warfarin or R-warfarin and had no impact on protrombi new time induced by warfarin.
Tadalafil potentsiyuvav no increase in bleeding time caused by acetyl salicylic acid.
Tadalafil has no vazodylyator system properties that may increase the hypotensive effects of antihypertensive drugs. Also in patients with poor control of hypertension Vano taking several hipotenziynyh drugs sposterihalosbilshe lower blood pressure. In most patients, reducing pressure not accompanied by hypotensive symptoms. It is necessary to give appropriate advice to patients treated with antihypertensive drugs and Cialis. Significant reduction in blood pressure is not sposterihalosu patients taking Cialis and selective a-1-blocker tamsulosin.